Department of Bioengineering,
School of Engineering,

The University of Tokyo


Masatoshi Yamazaki

Masatoshi Yamazaki

Associate Professor


Optical Mapping of Rotor as a Mechanism of Cardiac Fibrillation



Purpose of Research

Since about 100 years ago, many theoretical and experimental studies have suggested that rotor (a.k.a. 2-dimensional spiral wave reentry/3-d scroll wave) rotating around a functional obstacle, like hurricane and tornado, is the major mechanisms of cardiac fibirillation. Our objectives are first to explore spiral wave dynamics specifically in remodeled atria of chronic atrial fibrillation using high resolution optical mapping system and computer simulation; and second to examine how radio-frequency ablation of spiral wave effectively terminates and prevents cardiac fibrillation.

Subjects of Reseach

Dynamics of impulse propagation and rotational activity (rotor)
Atrial Fibrillation and 3-Dimensional Scroll Wave
Mechanisms of Ventricular Fibrillation (VF) and VF storm


Establishment of a Novel Therapeutic Strategy for Cardiac Fibrillation



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